CSL Reporter - HEK293 Cell line

Product Code
AMS.79754
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The Notch CSL Reporter - HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) stably integrated into HEK293 cells. Transfection of this cell line with a Notch expression vector and activation of the Notch pathway leads to expression of luciferase reporter. This cell line is validated with a Notch1DelE expression vector/ which is constitutively processed by ?-secretase/ leading to the release of NICD and the expression of luciferase.
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SKU AMS.79754
Size 2 vials
Species Human
Cell Line HEK293
Application • Monitor Notch signaling pathway activity.
• Screen for inhibitors of the Notch signaling pathway
• Test synthetic Notch receptors (synNotch) or other genetic constructs that conditionally activate the CSL promoter
Gene synonyms Notch reporter, PKA reporter, cAMP reporter, luciferase reporter , CSL reporter, CBF1 reporter, RBP-J reporter, Cell based assay kit, cell-based assay, reporter assay kit
Storage Immediately upon receipt/ store cells in liquid nitrogen.
Shipping Temp -80C (dry ice)
Supplier Name BPS