c-CBL TR-FRET Assay Kit

Name: c-CBL TR-FRET Assay Kit
Brand: AMS.79786
SKU: AMS.79786
Availability: InStock

Product Code

AMS.79786

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Overview

Casitas B lineage lymphoma (c-Cbl) is a multifunctional protein with ubiquitin E3 ligase activity capable of degrading diverse sets of proteins. c-Cbl is a ubiquitously expressed mammalian protein that plays a vital role in fundamental cellular functions including cell survival|migration|and proliferation. Recent evidence suggests a critical role for c-Cbl in angiogenesis and human solid organ tumors|making it a potential drug target in cancer immunotherapy. The c-CBL TR-FRET Assay Kit is designed to measure c-CBL auto-ubiquitination activity in a homogeneous 384 reaction format. It utilizes Biotin-labeled Ubiquitin and a terbium-labeled anti-c-CBL antibody to complete the TR-FRET pairing. This FRET-based assay requires no time-consuming washing steps|making it especially suitable for high throughput screening applications.

Product Specifications

More Information
SKU	AMS.79786
Size	384 reactions
Application	Great for screening small molecular inhibitors for drug discovery and HTS applications.
Gene synonyms	CBL-2, Cbl Proto-Oncogene, Signal Transduction Protein CBL; Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase, c-CBL
Storage	At least 6 months from date of receipt when stored as directed.
Shipping Temp	-80C (dry ice)
Supplier Name	BPS

For more details visit our PROTACs page >For more details visit our Ubiquitination and Deubiquitination page >

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ALiCE® is a radically different approach to cell-free expression and a kit unlike any others.

ALiCE® is a radically different approach to cell-free expression and a kit unlike any others.

ALiCE® is a radically different approach to cell-free expression and a kit unlike any others.

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c-CBL TR-FRET Assay Kit

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