Bromodomains

Large portfolio of bromodomain-containing proteins

Bromodomains (BRDs) are protein domains that recognize and bind to acetylated lysine residues on nucleosomes. By transducing the signals conveyed by these residues, bromodomains found on chromatin-associated proteins are able to regulate gene expression by translating these signals into normal or abnormal phenotypes. Bromodomains play a key role in chromatin remodeling and are therefore crucial for epigenetic gene regulation.

Proteins containing bromodomains have been implicated in the development of a large number of diseases including cancer, obesity, inflammation and diabetes.

The Inhibitor Screening Assay Kits are designed to measure the inhibition of bromodomain protein binding to its substrate. The key to the Assay Kits is the highly specific binding of the bromodomains to the acetylated histone substrate.

NameDatasheetPacksize Order
ATAD2A Inhibitor Screening Assay Kit-384 reactions View
ATAD2B Inhibitor Screening Assay Kit-384 reactions View
BAZ2B Inhibitor Screening Assay Kit-384 reactions View
BRD1 Inhibitor Screening Assay Kit-384 reactions View
BRD2 (BD2) Inhibitor Screening Assay Kit-384 reactions View
BRD3 (BD2) Inhibitor Screening Assay Kit-384 reactions View
BRD4 (BD1) Inhibitor Screening Assay Kit384 reactions View
BRD4 (BD2) Inhibitor Screening Assay Kit-384 reactions View
BRD9 (BD1) Inhibitor Screening Assay Kit-384 reactions View
BRPF3 Inhibitor Screening Assay Kit-384 reactions View
CECR2 Inhibitor Screening Assay Kit-384 reactions View
CREBBP Inhibitor Screening Assay Kit-384 reactions View
SMARCA2 Inhibitor Screening Assay Kit-384 reactions View
SMARCA4/BRG1 Inhibitor Screening Assay Kit-384 reactions View
TAF1 (BD1/BD2) Inhibitor Screening Assay Kit-384 reactions View
TAF1 (BD2) Inhibitor Screening Assay Kit-384 reactions View
TAF1L (BD1/BD2) Inhibitor Screening Assay Kit-384 reactions View
TAF1L (BD2) Inhibitor Screening Assay Kit-384 reactions View
TRIM24 Inhibitor Screening Assay Kit-384 reactions View

The TR-FRET Assay Kits are designed to measure the inhibition of protein binding to its substrate in a homogeneous 384-well reaction format. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is straightforward and simple.

NameDatasheetPacksize Order
ATAD2A TR-FRET Assay Kit-384 reactions View
ATAD2B TR-FRET Assay Kit-384 reactions View
BPTF/FALZ TR-FRET Assay Kit-384 reactions View
BRD1 TR-FRET Assay Kit-384 reactions View
BRD2 (BD1+BD2) TR-FRET Assay Kit-384 reactions View
BRD3 (BD1+BD2) TR-FRET Assay Kit-384 reactions View
BRD4 (BD1) TR-FRET Assay Kit384 reactions View
BRD4 (BD1+BD2) TR-FRET Assay Kit384 reactions View
BRD4 (BD2) TR-FRET Assay Kit384 reactions View
BRD9 TR-FRET Assay Kit-384 reactions View
BRDT (BD1+BD2) TR-FRET Assay Kit-384 reactions View
BRPF3 TR-FRET Assay Kit-384 reactions View
CECR2 TR-FRET Assay Kit-384 reactions View
CREBBP TR-FRET Assay Kit-384 reactions View
TAF1 (BD1+BD2) TR-FRET Assay Kit-384 reactions View
TAF1 (BD2) TR-FRET Assay Kit-384 reactions View
TAF1L (BD1+BD2) TR-FRET Assay Kit-384 reactions View
TRIM24 TR-FRET Assay Kit-384 reactions View
WDR9/BRWD1 TR-FRET Assay Kit-384 reactions View

NameDatasheetPacksize Order
ASH1L, His-tag100 ug View
ATAD2A, GST-tag-100 ug View
ATAD2A, His-tag-100 ug View
ATAD2B (KIAA1240), GST-tag-100 ug View
ATAD2B (KIAA1240), His-tag-100 ug View
BAZ1A, GST-tag-100 ug View
BAZ1B, GST-tag-100 ug View
BAZ1B, His-tag-100 ug View
BAZ2B, His-tag-100 ug View
BRD1, GST-tag-100 ug View
BRD1, His-tag-100 ug View
BRD2 (BD1), GST-tag-100 ug View
BRD2 (BD1), His-tag-100 ug View
BRD2 (BD1+BD2), GST-tag-100 ug View
BRD2 (BD1+BD2), His-tag-100 ug View
BRD2 (BD2), GST-tag-100 ug View
BRD2 (BD2), His-tag-100 ug View
BRD3 (BD1), GST-tag-100 ug View
BRD3 (BD1), His-tag-100 ug View
BRD3 (BD1+BD2), GST-tag-100 ug View
BRD3 (BD1+BD2), His-tag-100 ug View
BRD3 (BD2), GST-tag-100 ug View
BRD3 (BD2), His-tag-100 ug View
BRD4 (BD1), GST-tag-100 ug View
BRD4 (BD1), His-tag-100 ug View
BRD4 (BD1+BD2)-100 ug View
BRD4 (BD1+BD2), GST-tag-100 ug View
BRD4 (BD1+BD2), His-tag-100 ug View
BRD4 (BD2), GST-tag-100 ug View
BRD4 (BD2), His-tag-100 ug View
BRD9, GST-tag-100 ug View
BRD9, His-tag-100 ug View
BRDT (BD1), GST-tag-100 ug View
BRDT (BD1), His-tag-100 ug View
BRDT (BD1+BD2), GST-tag-100 ug View
BRDT (BD2), GST-tag-100 ug View
BRDT (BD2), His-tag-100 ug View
BRPF1, His-tag-100 ug View
BRPF3, GST-tag-100 ug View
CECR2, GST-tag-100 ug View
CECR2, His-tag-100 ug View
CREBBP (KAT3A), GST-tag-100 ug View
CREBBP (KAT3A), His-tag-100 ug View
FALZ (BPTF), GST-tag-100 ug View
FALZ (BPTF), His-tag-100 ug View
GCN5 (727-837), His-tag-100 ug View
P300 (1046-1163), His-tag100 ug View
PB1 (BD4), His-tag-100 ug View
PB1 (BD6), His-tag-100 ug View
PCAF (KAT2B), His-tag-100 ug View
PHIP (BD1), GST-tag-100 ug View
PHIP (BD1), His-tag-100 ug View
SMARCA2, GST-tag-100 ug View
SMARCA2, His-Tag, Biotin-Labeled-50 ug View
SMARCA2, His-tag-100 ug View
SMARCA4 (BRG1), GST-tag-100 ug View
SMARCA4 (BRG1), His-tag-100 ug View
TAF1 (BD1), His-tag-100 ug View
TAF1 (BD1+BD2), GST-tag-100 ug View
TAF1 (BD2), GST-tag-100 ug View
TAF1 (BD2), His-tag-100 ug View
TAF1L (BD1), GST-tag-100 ug View
TAF1L (BD1), His-tag-100 ug View
TAF1L (BD1+BD2), GST-tag-100 ug View
TAF1L (BD2), GST-tag-100 ug View
TAF1L (BD2), His-tag-100 ug View
TRIM24 (TIF1), GST-tag-100 ug View
TRIM24 (TIF1), His-tag-100 ug View
TRIM28, GST-tag-100 ug View
TRIM28, His-tag-100 ug View
WDR9/BRWD1 (BD2), GST-tag-100 ug View
WDR9/BRWD1 (BD2), His-tag-100 ug View
ZMYND11, GST-tag-100 ug View
ZMYND8, GST-tag-100 ug View