Bromodomains
Large portfolio of bromodomain-containing proteins
Bromodomains (BRDs) are protein domains that recognize and bind to acetylated lysine residues on nucleosomes. By transducing the signals conveyed by these residues, bromodomains found on chromatin-associated proteins are able to regulate gene expression by translating these signals into normal or abnormal phenotypes. Bromodomains play a key role in chromatin remodeling and are therefore crucial for epigenetic gene regulation.
Proteins containing bromodomains have been implicated in the development of a large number of diseases including cancer, obesity, inflammation and diabetes.
Our Products
AMSBIO provides an ever-growing portfolio of bromodomains and kits suitable for bromodomain profiling, inhibitor screening assays, and drug discovery.
The Inhibitor Screening Assay Kits are designed to measure the inhibition of bromodomain protein binding to its substrate. The key to the Assay Kits is the highly specific binding of the bromodomains to the acetylated histone substrate.
| Name | Packsize | Order |
|---|---|---|
| ATAD2A Inhibitor Screening Assay Kit | 384 reactions | View |
| ATAD2B Inhibitor Screening Assay Kit | 384 reactions | View |
| BAZ2B Inhibitor Screening Assay Kit | 384 reactions | View |
| BRD1 Inhibitor Screening Assay Kit | 384 reactions | View |
| BRD2 (BD2) Inhibitor Screening Assay Kit | 384 reactions | View |
| BRD3 (BD2) Inhibitor Screening Assay Kit | 384 reactions | View |
| BRD4 (BD1) Inhibitor Screening Assay Kit | 384 reactions | View |
| BRD4 (BD2) Inhibitor Screening Assay Kit | 384 reactions | View |
| BRD9 (BD1) Inhibitor Screening Assay Kit | 384 reactions | View |
| BRPF3 Inhibitor Screening Assay Kit | 384 reactions | View |
| CECR2 Inhibitor Screening Assay Kit | 384 reactions | View |
| CREBBP Inhibitor Screening Assay Kit | 384 reactions | View |
| SMARCA2 Inhibitor Screening Assay Kit | 384 reactions | View |
| SMARCA4/BRG1 Inhibitor Screening Assay Kit | 384 reactions | View |
| TAF1 (BD1/BD2) Inhibitor Screening Assay Kit | 384 reactions | View |
| TAF1 (BD2) Inhibitor Screening Assay Kit | 384 reactions | View |
| TAF1L (BD1/BD2) Inhibitor Screening Assay Kit | 384 reactions | View |
| TAF1L (BD2) Inhibitor Screening Assay Kit | 384 reactions | View |
| TRIM24 Inhibitor Screening Assay Kit | 384 reactions | View |
The TR-FRET Assay Kits are designed to measure the inhibition of protein binding to its substrate in a homogeneous 384-well reaction format. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is straightforward and simple.
| Name | Packsize | Order |
|---|---|---|
| ATAD2A TR-FRET Assay Kit | 384 reactions | View |
| ATAD2B TR-FRET Assay Kit | 384 reactions | View |
| BPTF/FALZ TR-FRET Assay Kit | 384 reactions | View |
| BRD1 TR-FRET Assay Kit | 384 reactions | View |
| BRD2 (BD1+BD2) TR-FRET Assay Kit | 384 reactions | View |
| BRD3 (BD1+BD2) TR-FRET Assay Kit | 384 reactions | View |
| BRD4 (BD1) TR-FRET Assay Kit | 384 reactions | View |
| BRD4 (BD1+BD2) TR-FRET Assay Kit | 384 reactions | View |
| BRD4 (BD2) TR-FRET Assay Kit | 384 reactions | View |
| BRD9 TR-FRET Assay Kit | 384 reactions | View |
| BRDT (BD1+BD2) TR-FRET Assay Kit | 384 reactions | View |
| BRPF3 TR-FRET Assay Kit | 384 reactions | View |
| CECR2 TR-FRET Assay Kit | 384 reactions | View |
| CREBBP TR-FRET Assay Kit | 384 reactions | View |
| TAF1 (BD1+BD2) TR-FRET Assay Kit | 384 reactions | View |
| TAF1 (BD2) TR-FRET Assay Kit | 384 reactions | View |
| TAF1L (BD1+BD2) TR-FRET Assay Kit | 384 reactions | View |
| TRIM24 TR-FRET Assay Kit | 384 reactions | View |
| WDR9/BRWD1 TR-FRET Assay Kit | 384 reactions | View |
| Name | Packsize | Order | |
|---|---|---|---|
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