ARE Luciferase Reporter Lentivirus
Product Code
AMS.79869
$0.00
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The Nrf2 antioxidant response pathway plays an important role in the cellular antioxidant defense. Nrf2/ a basic leucine zipper transcription factor/ induces the expression of antioxidant and phase II enzymes by binding to the ARE (antioxidant response element) region of the gene promoter. Under basal conditions/ Nrf2 is retained in the cytosol by binding to the cytoskeletal protein Keap1. Upon exposure to oxidative stress or other ARE activators/ Nrf2 is released from Keap1 and translocates to the nucleus/ where it can bind to the ARE/ leading to the expression of antioxidant and phase II enzymes that protect the cell from oxidative damage.
The ARE Luciferase Reporter Lentivirus are replication incompetent/ HIV-based/ VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells/ including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by ARE located upstream of the minimal TATA promoter. After transduction/ activation of the Nrf2 antioxidant response pathway in the target cells can be monitored by measuring the luciferase activity.
The ARE Luciferase Reporter Lentivirus are replication incompetent/ HIV-based/ VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells/ including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by ARE located upstream of the minimal TATA promoter. After transduction/ activation of the Nrf2 antioxidant response pathway in the target cells can be monitored by measuring the luciferase activity.
| SKU | AMS.79869 |
|---|---|
| Size | 500 ul x 2 |
| Gene symbol | ARE cell line, Nrf2 reporter, Nrf, Hepg2, ARE, HIV-based, VSV-G |
| Application | • Screen for activators or inhibitors of the Nrf2 antioxidant response pathway in the transduced target cells • Generation of ARE Luciferase Reporter stable cell line |
| Gene synonyms | ARE cell line, Nrf2 reporter, Nrf, Hepg2, ARE, HIV-based, VSV-G |
| Storage | Lentiviruses are shipped with dry ice. For long term storage/ it is recommended to store the virus at -80C. Titers can drop significantly with each freeze/thaw cycle. |
| Shipping Temp | -80C (dry ice) |
| Supplier Name | BPS |