AP1 Luciferase Reporter Lentivirus (JNK Signaling Pathway)

Product Code
79823
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The stress-activated protein kinase/c-jun N-terminal kinase (SAPK/JNK) family of proteins includes mitogen-activated protein kinases (MAPKs) that are activated by stress/ inflammatory cytokines/ mitogens/ oncogenes/ and inducers of cell differentiation and morphogenesis. Upon activation of the SAPK/JNK pathway/ MAP Kinase Kinases phosphorylate and activate JNKs. The activated JNKs translocate to the nucleus where they phosphorylate and activate transcription factors such as c-Jun. c-Jun then binds to the activator protein-1 (AP1) response element and induces AP1 transcription.
The AP1 Luciferase Reporter Lentivirus are replication incompetent/ HIV-based/ VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells/ including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by AP1 response element located upstream of the minimal TATA promoter. After transduction/ activation of the JNK signaling pathway and AP1 mediated activity in the target cells can be monitored by measuring the luciferase activity.
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SKU 79823
Size 500 ul x 2
Alternate SKU AMS.79823
Gene symbol JNK reporter, AP-1 cell line, activator protein-1 lentivirus
Application • Screen for activators or inhibitors of the JNK signaling pathway in the transduced target cells • Generation of AP1 Luciferase Reporter stable cell line
Gene synonyms JNK reporter, AP-1 cell line, activator protein-1 lentivirus
Storage Lentiviruses are shipped with dry ice. For long term storage/ it is recommended to store the virus at -80C. Avoid repeated freeze-thaw cycles. Titers can drop significantly with each freeze-thaw cycle.
Shipping Temp -80C (dry ice)
Supplier Name BPS