Anti-FoxO1a Rabbit Monoclonal Antibody
Product Code
M00073
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Monoclonal antibody for FKHR/FOXO1 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: IF, IHC, ICC, WB. Reactive species: Human, Mouse, Rat FKHR/FOXO1 information: Molecular Weight: 69662 MW; Subcellular Localization: Cytoplasm . Nucleus . Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells. In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway. Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation. Phosphorylation by NLK results in nuclear export. Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1. SGK1-mediated phosphorylation also results in nuclear translocation. Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide. Retained in the nucleus on methylation; Tissue Specificity: Ubiquitous.
SKU | M00073 |
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Size | 100 ul |
Host species | Rabbit |
Gene symbol | FOXO1 |
Application | WB, IHC, IF, ICC |
Species reactivity | Human, Mouse, Rat |
Accession No | Q12778 |
Gene id | 2308 |
Gene synonyms | Forkhead box protein O1;Forkhead box protein O1A;Forkhead in rhabdomyosarcoma;FOXO1;FKHR, FOXO1A; |
Format | Liquid |
Storage | At -20°C for one year. Avoid repeated freezing and thawing. |
Shipping Temp | Dry Ice |
Supplier Name | Boster Biological Technology Ltd |
Research Areas | Cancer Research, Epigenetics, Metabolism |