Anti-CDK5 Rabbit Monoclonal Antibody

Product Code
M00511
$370.00
Order Support
Shipping Information
Product Updates
  • Keep up to date with product offers, resources and news

  • Sign up

Monoclonal antibody for CDK5 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: Flow Cytometry, IP, IHC, WB. Reactive species: Human, Mouse, Rat CDK5 information: Molecular Weight: 33304 MW; Subcellular Localization: Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium . Cell projection, growth cone . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this att
More Information
SKU M00511
Size 100 ul
Host species Rabbit
Gene symbol CDK5
Application WB, IHC, IP
Species reactivity Human, Mouse, Rat
Accession No Q00535
Gene id 1020
Gene synonyms Cyclin-dependent-like kinase 5;2.7.11.1;Cell division protein kinase 5;Serine/threonine-protein kinase PSSALRE;Tau protein kinase II catalytic subunit;TPKII catalytic subunit;CDK5;CDKN5;
Format Liquid
Storage At -20°C for one year. Avoid repeated freezing and thawing.
Shipping Temp Dry Ice
Supplier Name Boster Biological Technology Ltd
Research Areas Cancer Research, Metabolism, Neuroscience