Anti-CDK5 Rabbit Monoclonal Antibody
Product Code
M00511
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Monoclonal antibody for CDK5 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: Flow Cytometry, IP, IHC, WB. Reactive species: Human, Mouse, Rat CDK5 information: Molecular Weight: 33304 MW; Subcellular Localization: Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium . Cell projection, growth cone . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this att
SKU | M00511 |
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Size | 100 ul |
Host species | Rabbit |
Gene symbol | CDK5 |
Application | WB, IHC, IP |
Species reactivity | Human, Mouse, Rat |
Accession No | Q00535 |
Gene id | 1020 |
Gene synonyms | Cyclin-dependent-like kinase 5;2.7.11.1;Cell division protein kinase 5;Serine/threonine-protein kinase PSSALRE;Tau protein kinase II catalytic subunit;TPKII catalytic subunit;CDK5;CDKN5; |
Format | Liquid |
Storage | At -20°C for one year. Avoid repeated freezing and thawing. |
Shipping Temp | Dry Ice |
Supplier Name | Boster Biological Technology Ltd |
Research Areas | Cancer Research, Metabolism, Neuroscience |