ActiveMax® Human Cytokines
The ideal choice for human cell culture and assay development
ActiveMax® Human Cytokines is our flagship product line featuring a complete collection of commonly used human cytokines and growth factors. Unlike most other commercially available cytokine products, ActiveMax® cytokines are expressed exclusively in human cells under strict animal free and xeno-free conditions. Therefore, they are uniquely suitable for human cell culture and assay development.
Features
- Authentic Post-translational Modification
- Tag-Free
- Endotoxin-Free
- Xeno-Free
- High Bioactivity
- High Stability
- High Purity
Here are some of the reasons why you should choose ActiveMax® cytokines for your studies:
Authentic Human Protein
The function of a protein heavily depends on its post translational processing, such as glycosylation, folding, and subunit assembly. Human recombinant proteins expressed from bacteria, insect, or non-human mammalian cells often fall short in fully recapitulating the post-translational modifications of their native counterparts, largely due to lack of human-specific mechanisms in the hosts. Consequently, these proteins often demonstrate compromised biological properties.
The production of ActiveMax® cytokines relies entirely on the human cellular machinery provided by the HEK293 cells. As a result, our cytokines retain their authentic post-translational processing (Fig. 1), which translates into high bioactivity and stability (Fig. 2). In addition, the HEKMax® system confers very high level of target expression, which allows us to purify proteins without the use of artificially introduced tags. This true tag-free production brings the benefit of fully maintaining the proteins’ native conformation and biological properties, including ligand-receptor binding affinity, which may be affected by subtle charge/size changes caused by the addition of tags.
Expression System | Folding | Phoshorylation | Proteolytic | Glycoslyation |
---|---|---|---|---|
E.coli | + | N/A | N/A | N/A |
Insect Cell | ++ | ++ | + | Poor |
Plant Cell | +++ | ++ | ++ | Poor |
CHO Cell | ++++ | +++ | +++ | Non-Human Like |
HEK293T | ++++ | ++++ | ++++ | Human Authentic |
Xeno-Free and Endotoxin-Free
Endotoxin and other non–human components can provoke an immune response in human systems. These contaminations are significant complicating factors for human cell culture experiments, in particular those relevant to human cell therapy or other clinical applications. Our ActiveMax® cytokines are exclusively produced in a serum-free, animal component-free, and chemically defined cell culture system. These cytokines are absolutely xeno-free, and have an endotoxin level of less than 1.0 EU per μg.
Bulk Production
Our HEKMax® technology platform employs a high density cell culture system, specially designed expression vectors, and proprietary HEK293 cell lines with a low background and an optimal metabolic profile. The seamless integration of these elements allows us to easily scale up our production to meet your demand for bulk amounts of cytokines. With this refined expression system in place, you can enjoy the benefits of an industrial production process with a highly affordable price.
Name | Datasheet | Packsize | Order |
---|---|---|---|
ActiveMax® Human SCF / KITLG Protein, Tag Free | - | 1 mg | View |
ActiveMax® Human SCF / KITLG Protein, Tag Free | - | 20 ug | View |
ActiveMax® Human SCF / KITLG Protein, Tag Free | - | 50 ug | View |
ActiveMax® Human TNF-alpha Protein, Tag Free, low endotoxin (active trimer) (MALS verified) | 25 ug | View | |
ActiveMax® Human VEGF110 Protein, Tag Free (MALS verified) | - | 20 ug | View |
ActiveMax® Human VEGF110 Protein, Tag Free (MALS verified) | - | 200 ug | View |
ActiveMax® Human VEGF110 Protein, Tag Free (MALS verified) | - | 500 ug | View |
Human Activin A / INHBA Protein, premium grade | - | 1 mg | View |
Human Activin A / INHBA Protein, premium grade | - | 100 ug | View |
Human Activin A / INHBA Protein, premium grade | - | 25 ug | View |
Human Erythropoietin / EPO Protein, premium grade | - | 50 ug | View |
Human Erythropoietin / EPO Protein/ premium grade | 20ug | View | |
Human Flt-3 Ligand Protein, premium grade | - | 1 mg | View |
Human Flt-3 Ligand Protein/ premium grade | - | 20ug | View |
Human Flt-3 Ligand Protein/ premium grade | - | 50ug | View |
Human G-CSF Protein, premium grade | - | 1 mg | View |
Human G-CSF Protein, premium grade | - | 50 ug | View |
Human GM-CSF Protein, premium grade | - | 1 mg | View |
Human GM-CSF Protein/ premium grade | - | 20ug | View |
Human GM-CSF Protein/ premium grade | - | 50ug | View |
Human IFN-gamma / IFNG Protein, premium grade | - | 100 ug | View |
Human IFN-gamma / IFNG Protein/ premium grade | - | 1mg | View |
Human IL-4 Protein, premium grade | - | 20 ug | View |
Human IL-4 Protein/ premium grade | - | 50ug | View |
Human IL-6 Protein, premium grade | - | 20 ug | View |
Human IL-6 Protein/ premium grade | - | 50ug | View |
Human LIF Protein, premium grade | - | 1 mg | View |
Human LIF Protein, premium grade | 20 ug | View | |
Human LIF Protein, premium grade | - | 50 ug | View |
Human Oncostatin M (OSM) Protein, premium grade | - | 1 mg | View |
Human Oncostatin M (OSM) Protein, premium grade | - | 50 ug | View |
Human TGF-Beta 1 / TGFB1 Protein, premium grade | - | 1 mg | View |
Human TGF-Beta 1 / TGFB1 Protein, premium grade | - | 50 ug | View |
Human TNF-alpha Protein, premium grade | 1 mg | View | |
Human TNF-alpha Protein, premium grade | 100 ug | View | |
Human VEGF121 Protein, premium grade | - | 1 mg | View |
Human VEGF121 Protein, premium grade | - | 20 ug | View |
Human VEGF121 Protein, premium grade | - | 50 ug | View |
Human VEGF165 Protein, premium grade | - | 1 mg | View |
Human VEGF165 Protein, premium grade | - | 50 ug | View |
Mouse VEGF120 Protein, Tag Free | - | 1 mg | View |
Mouse VEGF120 Protein, Tag Free | - | 20 ug | View |
Mouse VEGF120 Protein, Tag Free | - | 50 ug | View |
Mouse VEGF164 Protein, Tag Free (HPLC-verified) | - | 20 ug | View |
Mouse VEGF164 Protein, Tag Free (HPLC-verified) | - | 50 ug | View |