S-Adenosylmethionine and Methylation

S-Adenosylmethionine (also known as SAM-e, SAMe, SAM, AdoMet, or ademetionine) is a critical metabolite found in all living cells. SAM-e plays a central role in cellular biochemistry, acting as a donor of methyl groups in numerous methylation reactions as well as being a precursor molecule to both the aminopropylation and transulfuration pathways.

  • Depression
  • Parkinson's disease
  • Osteoarthritis symptoms
  • Liver disease
  • Intrahepatic cholestasis (of pregnancy especially)
  • Fibromyalgia
  • AIDS-related myelopathy

There has be also limited research that has referenced for SAM-e's role in the following conditions:

  • Attention deficit hyperactivity disorder (ADHD)
  • Premenstrual syndrome (PMS)
  • Premenstrual dysphoric disorder (PMDD)
  • Chronic fatigue syndrome (CFS)
  • Heart disease
  • Defective intellectual performance
  • Multiple sclerosis
  • Dementia
  • Alzheimer’s disease
  • Tendonitis
  • Bursitis
  • Spinal cord injury
  • Seizure
  • Migraine headache
  • Chronic low back pain
  • Lead poisoning
  • Aging