AMSBIO offers primary human cancer cells sourced from a variety of tissue types that allow the study of cancer in a more in vivo like fashion.
- Tumor cell specific amplications and mutation present , e.g. heterozygous Tp53
- Original tumour pathology available for each Lot of cells
- Cells exhibit heterogenous cell population with diverse genetic background
- Not adapted to the in vitro environment
- Cells avialable from specific tumour types, primary and metastasis
Despite significant advances in cancer research and treatments, the eradication of the disease remains elusive. This has led to a more urgent focus on
precision medicine and advanced treatments like immunotherapy and the use of oncolytic viruses. Donor derived primary tumor cells offer a more in vivo like model potentially
enhancing the development of targeted personalized therapeutics.
It is known that using immortalized cell lines as surrogates poorly reflects the diverse profiles tumors have. During long-term culture immortalized cells adapt to
their in vitro environment, and often mask or lose the in vivo phenotypic events being studied in addition to hiding key epigenetic or immunotherapy markers. These shortfalls highlight
a need for new in vitro cancer models that utilize primary tumor cells that more closely reproduce the in vivo cancer microenvironment.
Provided with the original pathological diagnoses and analyzed for key mutations, AMSBIO primary human cancer cells present the real characteristics of their in vivo
state, remain heterogeneous for several passages and thus enhance pharmacogenetic and molecular diagnostic testing abilities. These patient specific cells add to a range of products
offered by AMSBIO to help researchers develop more physiologically relevant models to study cell behavior.
Figure 1. Immunocytochemical analysis of human primary breast cancer cells in vitro, EGFR expression (red) and TP53 (green), DAPI blue.
Figure 2. Immunocytochemical analysis of human primary prostate cancer cells in vitro. EGFR expression (red) and pan-Cytokeratin expression TP53 (green), DAPI (blue).