amsbio is pleased to announce an expanded range of
assay kits enzymes and antibodies for the
detection & quantification of oxidative stress biomarkers and antioxidants.
Reduction of oxygen results in the formation of
reactive oxygen species (ROS), such as
hydrogen peroxide, hydroxyl radicals and superoxide. These are directly responsible for the detrimental effects of
oxidative stress.
Generation of reactive oxygen species is linked to a variety of environmental factors like ultraviolet radiation & cigarette smoking. To counteract the effects of ROS
in vivo, there are a number of distinct antioxidant mechanisms in place within the
cell,
such as
superoxide dismutase, catalase, ascorbic acid, and glutathione.
Oxidative stress & associated damage to
cellular lipids, proteins and
DNA occur when these compensatory mechanisms fail to deal with the increasing loads of ROS.
Elevated levels of ROS contribute to a decline in cellular function, and have been reported to coincide with pathologies including
cancer, cardiovascular disease and
neurological disorders.