AMSBIO supplies a unique range of highly active enzymes, including demethylases, methyltransferases, HDACs, poly-ADP-ribose polymerases, DPPs, and ubiquitin pathway proteins, as well as an extensive portfolio of kinases, phosphodiesterases, phosphatases, and cytokines.
These cover a collection of tools for profiling and inhibitor screening activity assays for drug discovery.
We also provide a broad selection of direct activity assay kits, in addition to our
custom protein expression
and profiling services.
Histone Methylation |
Important drug discovery targets: histone methyltransferases and histone demethylases.
Our histone methylation product range includes substrates, enzymes and assays for PRMTs, EZHs, NSDs, SETDs, and SUVs.
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DNA
Methylation |
Methylation of DNA is required for gene regulation playing a crucial role in the development of cancer.
We offer several DNMT assay kits and enzymes for measuring DNMT activity or inhibitors in cells.
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Histone Acetylation |
Histone deacetylases (HDACs) repress transcription, and HDAC inhibitors (HDIs) are potent inducers of growth arrest, differentiation, and apoptosis.
This makes HDIs key targets for drug discovery.
AMSBIO offers a complete panel of HDAC and sirtuin reagents, including enzymes, substrates, and assay kits.
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Bromodomains |
Bromodomains
(BRDs) are emerging as a new class of targets which will be important in cancer drug discovery as well as treatments of inflammatory diseases.
AMSBIO provides a portfolio of BRDs and kits suitable for bromodomain profiling, inhibitor screening assays, and drug discovery.
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PARP |
AMSBIO provide a selection of
PARP
enzymes and kits.
Poly (ADP-Ribose) Polymerase (PARP) is involved in chromatin remodeling, and cellular processes involving DNA repair and programmed cell death.
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Kinases |
AMSBIO provide a selection of
PARP
AMSBIO offers a broad range of kinase enzymes and substrates, including; receptor tyrosine kinases, non-receptor tyrosine kinases, lipid kinases, and serine/threonine kinases.
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Protein phosphatases |
AMSBIO offer a collection of enzymes of both protein tyrosine phosphatases (PTPs) and the transmembrane receptor protein tyrosine phosphatases (RPTPs).
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Proteases |
Proteases offer a valuable target in many therapeutic settings, including Alzheimer's, cancer, and viral infection.
AMSBIO offer assay kits, enzymes and substrates for a range of important proteases, such as caspases, DPPs, Cathepsins, and HCVs.
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Ubiqitination and Deubiquitination |
AMSBIO provides many unique enzymes for the study of ubiquitin regulated pathways such as apoptosis, DNA repair, epigenetic modification of histones, and embryonic development.
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Phosphodiesterases |
Phosphodiesterases (PDEs) play an important role in the dynamic regulation of cAMP and cGMP signalling. AMSBIO provides PDE kits to identify PDE inhibitors, and PDE enzymes for enzyme kinetic studies.
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Cytokines and growth factors |
AMSBIO provides the highest quality
cytokines
and growth factors for optimal cell growth and development. Every lot is tested for biological potency and cell proliferation.
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Protein arginine deiminases |
Protein arginine deiminases (PADs) activity is associated with several diseases, including rheumatoid arthritis, Alzheimer's disease multiple sclerosis, lupus, Parkinson's disease, and cancer.
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Custom screening services |
AMSBIO offers a
custom screening services
including an array of high quality recombinant enzymes for selectivity profiling and inhibitor screening.
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