Bromodomains

AMSBIO supplies a unique range of products for bromodomain research. Bromodomains are protein domains that recognise acetylated lysine. They are implicated in cancer, obesity, inflammation and diabetes. They play an important role in epigenetics.

AMSBIO provides an ever-growing portfolio of BRDs and kits suitable for bromodomain profiling, inhibitor screening assays, and drug discovery.

The Inhibitor Screening Assay Kits are designed to measure the inhibition of bromodomain protein binding to its substrate. The key to the Assay Kits is the highly specific binding of the bromodomains to the acetylated histone substrate.

Product list:

Cat #	Description	Pack Size
32514	BRD4 (BD1) Inhibitor Screening Assay Kit	384 rxns.
32524	BRD4 (BD2) Inhibitor Screening Assay Kit	384 rxns.
32513	BRD3 (BD1) Inhibitor Screening Assay Kit	384 rxns.
32523	BRD3 (BD2) Inhibitor Screening Assay Kit	384 rxns.
32601	ATAD2A Inhibitor Screening Assay Kit	384 rxns.
32600	BAZ2B Inhibitor Screening Assay Kit	384 rxns.
32602	TAF1L (BD2) Inhibitor Screening Assay Kit	384 rxns.
32604	TAF1 (BD1/BD2) Inhibitor Screening Assay Kit	384 rxns.
32603	TAF1L (BD1/BD2) Inhibitor Screening Assay Kit	384 rxns.
32522	BRD2 (BD2) Inhibitor Screening Assay Kit	384 rxns.
32609	SMARCA4/BRG1 Inhibitor Screening Assay Kit	384 rxns.
32608	BRPF3 Inhibitor Screening Assay Kit	384 rxns.
32611	CECR2 Inhibitor Screening Assay Kit	384 rxns.
32610	SMARCA2 Inhibitor Screening Assay Kit	384 rxns.
32607	CREBBP Inhibitor Screening Assay Kit	384 rxns.
32606	TRIM24 Inhibitor Screening Assay Kit	384 rxns.
32521	BRD1 Inhibitor Screening Assay Kit	384 rxns.
32519	BRD9 (BD1) Inhibitor Screening Assay Kit	384 rxns.

The TR-FRET Assay Kits are designed to measure the inhibition of protein binding to its substrate in a homogeneous 384 reaction format. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is straightforward and simple.

Product list:

Cat #	Description	Pack Size
32612	BRD4 (BD1+BD2) TR-FRET Assay Kit	384 rxns.
32613	BRD4 (BD1) TR-FRET Assay Kit	384 rxns.
32614	BRD2 (BD1+BD2) TR-FRET Assay Kit	384 rxns.
32615	BRD3 (BD1+BD2) TR-FRET Assay Kit	384 rxns.
32616	BRDT (BD1+BD2) TR-FRET Assay Kit	384 rxns.
32617	BRD4 (BD2) TR-FRET Assay Kit	384 rxns.
32618	ATAD2A TR-FRET Assay Kit	384 rxns.
32619	CREBBP TR-FRET Assay Kit	384 rxns.
32620	ATAD2B TR-FRET Assay Kit	384 rxns.
32621	BRD9 TR-FRET Assay Kit	384 rxns.
32622	CECR2 TR-FRET Assay Kit	384 rxns.
32625	BRD1 TR-FRET Assay Kit	384 rxns.
32626	BRPF3 TR-FRET Assay Kit	384 rxns.
32627	TAF1 (BD2) TR-FRET Assay Kit	384 rxns.
32628	TAF1 (BD1+BD2) TR-FRET Assay Kit	384 rxns.
32629	TAF1L (BD1+BD2) TR-FRET Assay Kit	384 rxns.
32630	TRIM24 TR-FRET Assay Kit	384 rxns.
32631	WDR9/BRWD1 TR-FRET Assay Kit	384 rxns.
32632	BPTF/FALZ TR-FRET Assay Kit	384 rxns.

Product list:

Cat #	Description	Pack Size
31025	BRD2 (BD1+BD2), His-tag	100 ug
31045	BRD4 (BD1+BD2), His-tag	100 ug
31119	CREBBP (KAT3A), His-tag	100 ug
31118	P300 (1046-1163), His-tag	100 ug
31060	BRDT (BD2), GST-tag	100 ug
31061	BRDT (BD1+BD2), GST-tag	100 ug
31123	TAF1 (BD1), His-tag	100 ug
31034	BRD3 (BD1+BD2), His-tag	100 ug
31035	BRD3 (BD1+BD2), GST-tag	100 ug
31124	TAF1 (BD1+BD2), GST-tag	100 ug
31126	TAF1 (BD2), GST-tag	100 ug
31031	BRD3 (BD2), His-tag	100 ug
31033	BRD3 (BD2), GST-tag	100 ug
31030	BRD3 (BD1), His-tag	100 ug
31032	BRD3 (BD1), GST-tag	100 ug
31020	BRD2 (BD2), His-tag	100 ug
31022	BRD2 (BD1), His-tag	100 ug
31021	BRD2 (BD1), GST-tag	100 ug
31023	BRD2 (BD2), GST-tag	100 ug
31010	BRD1, His-tag	100 ug
31040	BRD4 (BD1), GST-tag	100 ug
31041	BRD4 (BD2), GST-tag	100 ug
31102	SMARCA4 (BRG1), His-tag	100 ug
31043	BRD4 (BD2), His-tag	100 ug
31104	TAF1L (BD2), His-tag	100 ug
31101	BRDT (BD1), His-tag	100 ug
31042	BRD4 (BD1), His-tag	100 ug
31103	TAF1L (BD1), His-tag	100 ug
31100	BRDT (BD2), His-tag	100 ug
31090	BRD9, His-tag	100 ug
31105	TAF1L (BD1), GST-tag	100 ug
31106	TAF1L (BD2), GST-tag	100 ug
31107	TAF1L (BD1+BD2), GST-tag	100 ug
31024	BRD2 (BD1+BD2), GST-tag	100 ug
31011	BRD1, GST-tag	100 ug
31108	BRDT (BD1), GST-tag	100 ug
31109	ATAD2A, His-tag	100 ug
31110	TAF1 (BD2), His-tag	100 ug
31111	SMARCA2, His-tag	100 ug
31113	BAZ2B, His-tag	100 ug
31112	BRPF1, His-tag	100 ug
31114	GCN5 (727-837), His-tag	100 ug
31115	WDR9/BRWD1 (BD2), His-tag	100 ug
31116	TRIM24 (TIF1), His-tag	100 ug
31125	ATAD2B (KIAA1240), GST-tag	100 ug
31117	ATAD2B (KIAA1240), His-tag	100 ug
31044	BRD4 (BD1+BD2), GST-tag	100 ug
31122	PB1 (BD4), His-tag	100 ug
31120	PCAF (KAT2B), His-tag	100 ug
31121	ATAD2A, GST-tag	100 ug
31141	SMARCA2, GST-tag	100 ug
31133	PB1 (BD6), His-tag	100 ug
31131	FALZ (BPTF), His-tag	100 ug
31046	CECR2, His-tag	100 ug
31130	BRPF3, GST-tag	100 ug
31047	BRD4 (BD1+BD2)	100 ug
31132	SMARCA4 (BRG1), GST-tag	100 ug
31137	BAZ1B, GST-tag	100 ug
31145	BAZ1B, His-tag	100 ug
31144	ZMYND11, GST-tag	100 ug
31147	ASH1L, His-tag	100 ug
31146	TRIM28, His-tag	100 ug
31143	ZMYND8, GST-tag	100 ug
31142	PHIP (BD1), GST-tag	100 ug
31140	PHIP (BD1), His-tag	100 ug
31139	TRIM28, GST-tag	100 ug
31138	CECR2, GST-tag	100 ug
31136	BAZ1A, GST-tag	100 ug
31135	WDR9/BRWD1 (BD2), GST-tag	100 ug
31134	FALZ (BPTF), GST-tag	100 ug
31128	CREBBP (KAT3A), GST-tag	100 ug
31127	TRIM24 (TIF1), GST-tag	100 ug
31091	BRD9, GST-tag	100 ug