Bromodomains

AMSBIO supplies a unique range of products for bromodomain research. Bromodomains are protein domains that recognise acetylated lysine. They are implicated in cancer, obesity, inflammation and diabetes. They play an important role in epigenetics.

AMSBIO provides an ever-growing portfolio of BRDs and kits suitable for bromodomain profiling, inhibitor screening assays, and drug discovery.

Inhibitor screening assays

The Inhibitor Screening Assay Kits are designed to measure the inhibition of bromodomain protein binding to its substrate. The key to the Assay Kits is the highly specific binding of the bromodomains to the acetylated histone substrate.

Product list:

Cat #	Description	Pack Size
32514	BRD4 (BD1) Inhibitor Screening Assay Kit	384 reactions
32524	BRD4 (BD2) Inhibitor Screening Assay Kit	384 reactions
32513	BRD3 (BD1) Inhibitor Screening Assay Kit	384 reactions
32523	BRD3 (BD2) Inhibitor Screening Assay Kit	384 reactions
32601	ATAD2A Inhibitor Screening Assay Kit	384 reactions
32600	BAZ2B Inhibitor Screening Assay Kit	384 reactions
32602	TAF1L (BD2) Inhibitor Screening Assay Kit	384 reactions
32604	TAF1 (BD1/BD2) Inhibitor Screening Assay Kit	384 reactions
32603	TAF1L (BD1/BD2) Inhibitor Screening Assay Kit	384 reactions
32522	BRD2 (BD2) Inhibitor Screening Assay Kit	384 reactions
32609	SMARCA4/BRG1 Inhibitor Screening Assay Kit	384 reactions
32608	BRPF3 Inhibitor Screening Assay Kit	384 reactions
32611	CECR2 Inhibitor Screening Assay Kit	384 reactions
32610	SMARCA2 Inhibitor Screening Assay Kit	384 reactions
32607	CREBBP Inhibitor Screening Assay Kit	384 reactions
32606	TRIM24 Inhibitor Screening Assay Kit	384 reactions
32521	BRD1 Inhibitor Screening Assay Kit	384 reactions
32519	BRD9 (BD1) Inhibitor Screening Assay Kit	384 reactions

Homogenous assays

The TR-FRET Assay Kits are designed to measure the inhibition of protein binding to its substrate in a homogeneous 384 reaction format. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is straightforward and simple.

Product list:

Cat #	Description	Pack Size
32612	BRD4 (BD1+BD2) TR-FRET Assay Kit	384 reactions
32613	BRD4 (BD1) TR-FRET Assay Kit	384 reactions
32614	BRD2 (BD1+BD2) TR-FRET Assay Kit	384 reactions
32615	BRD3 (BD1+BD2) TR-FRET Assay Kit	384 reactions
32616	BRDT (BD1+BD2) TR-FRET Assay Kit	384 reactions
32617	BRD4 (BD2) TR-FRET Assay Kit	384 reactions
32618	ATAD2A TR-FRET Assay Kit	384 reactions
32619	CREBBP TR-FRET Assay Kit	384 Reactions
32620	ATAD2B TR-FRET Assay Kit	384 reactions
32621	BRD9 TR-FRET Assay Kit	384 reactions
32622	CECR2 TR-FRET Assay Kit	384 reactions
32625	BRD1 TR-FRET Assay Kit	384 reactions
32626	BRPF3 TR-FRET Assay Kit	384 reactions
32627	TAF1 (BD2) TR-FRET Assay Kit	384 reactions
32628	TAF1 (BD1+BD2) TR-FRET Assay Kit	384 reactions
32629	TAF1L (BD1+BD2) TR-FRET Assay Kit	384 reactions
32630	TRIM24 TR-FRET Assay Kit	384 reactions
32631	WDR9/BRWD1 TR-FRET Assay Kit	384 reactions
32632	BPTF/FALZ TR-FRET Assay Kit	384 reactions

BRD Proteins

Product list:

Cat #	Description	Pack Size
31025	BRD2 (BD1+BD2), His-tag Recombinant Protein	100 µg
31045	BRD4 (BD1+BD2), His-tag Recombinant Protein	100 µg
31119	CREBBP (KAT3A), His-tag Recombinant Protein	100 µg
31118	P300 (1046-1163), His-tag Recombinant Protein	100 µg
31060	BRDT (BD2), GST-tag Recombinant Protein	100 µg
31061	BRDT (BD1+BD2), GST-tag Recombinant Protein	100 µg
31123	TAF1 (BD1), His-tag Recombinant Protein	100 µg
31034	BRD3 (BD1+BD2), His-tag Recombinant Protein	100 µg
31035	BRD3 (BD1+BD2), GST-tag Recombinant Protein	100 µg
31124	TAF1 (BD1+BD2), GST-tag Recombinant Protein	100 µg
31126	TAF1 (BD2), GST-tag Recombinant Protein	100 µg
31031	BRD3 (BD2), His-tag Recombinant Protein	100 µg
31033	BRD3 (BD2), GST-tag Recombinant Protein	100 µg
31030	BRD3 (BD1), His-tag Recombinant Protein	100 µg
31032	BRD3 (BD1), GST-tag Recombinant Protein	100 µg
31020	BRD2 (BD2), His-tag Recombinant Protein	100 µg
31022	BRD2 (BD1), His-tag Recombinant Protein	100 µg
31021	BRD2 (BD1), GST-tag Recombinant Protein	100 µg
31023	BRD2 (BD2), GST-tag Recombinant Protein	100 µg
31010	BRD1, His-tag Recombinant Protein	100 µg
31040	BRD4 (BD1), GST-tag Recombinant Protein	100 µg
31041	BRD4 (BD2), GST-tag Recombinant Protein	100 µg
31102	SMARCA4 (BRG1), His-tag Recombinant Protein	100 µg
31043	BRD4 (BD2), His-tag Recombinant Protein	100 µg
31104	TAF1L (BD2), His-tag Recombinant Protein	100 µg
31101	BRDT (BD1), His-tag Recombinant Protein	100 µg
31042	BRD4 (BD1), His-tag Recombinant Protein	100 µg
31103	TAF1L (BD1), His-tag Recombinant Protein	100 µg
31100	BRDT (BD2), His-tag Recombinant Protein	100 µg
31090	BRD9, His-tag Recombinant Protein	100 µg
31105	TAF1L (BD1), GST-tag Recombinant Protein	100 µg
31106	TAF1L (BD2), GST-tag Recombinant Protein	100 µg
31107	TAF1L (BD1+BD2), GST-tag Recombinant Protein	100 µg
31024	BRD2 (BD1+BD2), GST-tag Recombinant Protein	100 µg
31011	BRD1, GST-tag Recombinant Protein	100 µg
31108	BRDT (BD1), GST-tag Recombinant Protein	100 µg
31109	ATAD2A, His-tag Recombinant Protein	100 µg
31110	TAF1 (BD2), His-tag Recombinant Protein	100 µg
31111	SMARCA2, His-tag Recombinant Protein	100 µg
31113	BAZ2B, His-tag Recombinant Protein	100 µg
31112	BRPF1, His-tag Recombinant Protein	100 µg
31114	GCN5 (727-837), His-tag Recombinant Protein	100 µg
31115	WDR9/BRWD1 (BD2), His-tag Recombinant Protein	100 µg
31116	TRIM24 (TIF1), His-tag Recombinant Protein	100 µg
31125	ATAD2B (KIAA1240), GST-tag Recombinant Protein	100 µg
31117	ATAD2B (KIAA1240), His-tag Recombinant Protein	100 µg
31044	BRD4 (BD1+BD2), GST-tag Recombinant Protein	100 µg
31122	PB1 (BD4), His-tag Recombinant Protein	100 µg
31120	PCAF (KAT2B), His-tag Recombinant Protein	100 µg
31121	ATAD2A, GST-tag Recombinant Protein	100 µg
31141	SMARCA2, GST-tag Recombinant Protein	100 µg
31133	PB1 (BD6), His-tag Recombinant Protein	100 µg
31131	FALZ (BPTF), His-tag Recombinant Protein	100 µg
31046	CECR2, His-tag Recombinant Protein	100 µg
31130	BRPF3, GST-tag Recombinant Protein	100 µg
31047	BRD4 (BD1+BD2) Recombinant Protein	100 µg
31132	SMARCA4 (BRG1), GST-tag Recombinant Protein	100 µg
31137	BAZ1B, GST-tag Recombinant Protein	100 µg
31145	BAZ1B, His-tag Recombinant Protein	100 µg
31144	ZMYND11, GST-tag Recombinant Protein	100 µg
31147	ASH1L, His-tag Recombinant Protein	100 µg
31146	TRIM28, His-tag Recombinant Protein	100 µg
31143	ZMYND8, GST-tag Recombinant Protein	100 µg
31142	PHIP (BD1), GST-tag Recombinant Protein	100 µg
31140	PHIP (BD1), His-tag Recombinant Protein	100 µg
31139	TRIM28, GST-tag Recombinant Protein	100 µg
31138	CECR2, GST-tag Recombinant Protein	100 µg
31136	BAZ1A, GST-tag Recombinant Protein	100 µg
31135	WDR9/BRWD1 (BD2), GST-tag Recombinant Protein	100 µg
31134	FALZ (BPTF), GST-tag Recombinant Protein	100 µg
31128	CREBBP (KAT3A), GST-tag Recombinant Protein	100 µg
31127	TRIM24 (TIF1), GST-tag Recombinant Protein	100 µg
31091	BRD9, GST-tag Recombinant Protein	100 µg

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