Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag

Name: Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag
Brand: AMS.TR1-H5254-1mg
SKU: AMS.TR1-H5254-1mg
Price: 2200 USD
Availability: InStock

Product Code

AMS.TR1-H5254-1mg

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$2,200.00

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Overview

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.

Product Specifications

More Information
SKU	AMS.TR1-H5254-1mg
Size	1 mg
Species	Human
Expression Host	HEK293
Gene symbol	TRAIL R1
aa sequence	Ala 24 - Asn 239
Tag	FC
Label/Conjugate	Unconjugated
Accession No	NP_003835
Gene synonyms	TNFRSF10A,TRAIL-R1,CD261,APO2,DR4
Format	Powder
Storage	-20C
Shipping Temp	RT
Supplier Name	ACROBiosystems Inc.

Images

Immobilized Human TRAIL R1, Fc Tag (Cat. No. TR1-H5254) at 5 ?g/mL (100 ?L/well) can bind Human TRAIL, Mouse IgG2a Fc Tag (Cat. No. TRL-H5259) with a linear range of 4-16 ng/mL (QC tested).

Human TRAIL R1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

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Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag

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