Mouse TIM-3 / HAVCR2 Protein, Fc Tag
Product Code
AMS.TI3-M5252-1mg
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Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
SKU | AMS.TI3-M5252-1mg |
---|---|
Size | 1 mg |
Species | Mouse |
Expression Host | HEK293 |
Gene symbol | TIM-3 |
aa sequence | Arg 20 - Arg 191 |
Tag | FC |
Label/Conjugate | Unconjugated |
Accession No | AAL65156.1 |
Gene synonyms | HAVCR2,TIM3,TIMD3,FLJ14428,KIM3 |
Format | Powder |
Storage | -20C |
Shipping Temp | RT |
Supplier Name | ACROBiosystems Inc. |