Human IL-12A / NKSF1 / p35 Protein, Fc Tag

Name: Human IL-12A / NKSF1 / p35 Protein, Fc Tag
Brand: AMS.NK1-H5252-50ug
SKU: AMS.NK1-H5252-50ug
Price: 315 USD
Availability: InStock

Product Code

AMS.NK1-H5252-50ug

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$315.00

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Overview

Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. Interleukin-12 subunit alpha (IL12A) also known as NKSF1, CLMF1 and P35, IL12A shows significant sequence similarity to IL-6, G-CSF, and exerts biological activities only when the IL12B is co-expressed. IL12B deficient mice are resistant to the induction of experimental chronic inflammatory diseases whereas IL12A knock-out mice develop more severe forms, suggesting opposite functions of the two subunits in the outcome of chronic inflammatory diseases.

Product Specifications

More Information
SKU	AMS.NK1-H5252-50ug
Size	50 ug
Species	Human
Expression Host	HEK293
Gene symbol	IL-12A
aa sequence	Arg 23 - Ser 219
Tag	FC
Label/Conjugate	Unconjugated
Accession No	N/A
Gene synonyms	IL12A,CLMF,IL-12A,NFSK,NKSF1,P35
Format	Powder
Storage	-20C
Shipping Temp	RT
Supplier Name	ACROBiosystems Inc.
Research Areas	Immunology

Images

Human IL-12A, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

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Human IL-12A / NKSF1 / p35 Protein, Fc Tag

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