Mouse LAIR1 / CD305 Protein, Mouse IgG2a Fc Tag, low endotoxin
Product Code
AMS.LA1-M5254-100ug
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Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.
SKU | AMS.LA1-M5254-100ug |
---|---|
Size | 100 ug |
Species | Mouse |
Expression Host | HEK293 |
Gene symbol | LAIR-1 |
aa sequence | Gln 22 - Tyr 141 |
Tag | FC |
Label/Conjugate | Unconjugated |
Accession No |  NP_001106945.1 |
Gene synonyms | LAIR1,CD305 |
Format | Powder |
Storage | -20C |
Shipping Temp | RT |
Supplier Name | ACROBiosystems Inc. |