Mouse LAIR1 / CD305 Protein, Mouse IgG2a Fc Tag, low endotoxin

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AMS.LA1-M5254-100ug
$440.00
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Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.
More Information
SKU AMS.LA1-M5254-100ug
Size 100 ug
Species Mouse
Expression Host HEK293
Gene symbol LAIR-1
aa sequence Gln 22 - Tyr 141
Tag FC
Label/Conjugate Unconjugated
Accession No  NP_001106945.1
Gene synonyms LAIR1,CD305
Format Powder
Storage -20C
Shipping Temp RT
Supplier Name ACROBiosystems Inc.