Human IL-1 RII / CD121b Protein, Fc Tag

Name: Human IL-1 RII / CD121b Protein, Fc Tag
Brand: AMS.IL2-H4256-1mg
SKU: AMS.IL2-H4256-1mg
Price: 2200 USD
Availability: InStock

Product Code

AMS.IL2-H4256-1mg

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$2,200.00

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Overview

Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Product Specifications

More Information
SKU	AMS.IL2-H4256-1mg
Size	1 mg
Species	Human
Expression Host	HEK293
Gene symbol	IL-1 RII
aa sequence	Phe 14 - Glu 343
Tag	FC
Label/Conjugate	Unconjugated
Accession No	NP_004624.1
Gene description	Human
Gene synonyms	CD121b,IL1RB,IL1R2,CDw121b
Format	Powder
Storage	-20C
Shipping Temp	RT
Supplier Name	ACROBiosystems Inc.

Images

Immobilized Human IL-1 beta, Tag Free (Cat. No. ILB-H4110) at 10 ?g/mL (100 ?L/well) can bind Human IL-1 RII, Fc Tag (Cat. No. IL2-H4256) with a linear range of 4-125 ng/mL (QC tested).

Human IL-1 RII, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

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Human IL-1 RII / CD121b Protein, Fc Tag

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