Cynomolgus CRTAM Protein, Fc Tag
Product Code
AMS.CRM-C5255-100ug
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Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.
SKU | AMS.CRM-C5255-100ug |
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Size | 100 ug |
Species | Monkey, Cynomolgus |
Expression Host | HEK293 |
Gene symbol | CRTAM |
aa sequence | Ser 18 - Gly 287 |
Tag | FC |
Label/Conjugate | Unconjugated |
Accession No | XP_005580021.1 |
Gene synonyms | CRTAM,CD355 |
Format | Powder |
Storage | -20C |
Shipping Temp | RT |
Supplier Name | ACROBiosystems Inc. |