Cynomolgus CRTAM Protein, Fc Tag

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AMS.CRM-C5255-100ug
$365.00
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Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.
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SKU AMS.CRM-C5255-100ug
Size 100 ug
Species Monkey, Cynomolgus
Expression Host HEK293
Gene symbol CRTAM
aa sequence Ser 18 - Gly 287
Tag FC
Label/Conjugate Unconjugated
Accession No XP_005580021.1
Gene synonyms CRTAM,CD355
Format Powder
Storage -20C
Shipping Temp RT
Supplier Name ACROBiosystems Inc.