Human CD14 Protein, Fc Tag (MALS verified)
Product Code
AMS.CD4-H5252-1mg
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Cluster of differentiation 14 (CD14), is a cell surface glycoprotein, and is a is a component of the innate immune system. CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa). CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP). CD14 has been proposed to be involved in various biological processes, including transportation of other lipids, cell-cell interaction during different immune responses, as well as recognition of apoptotic cells. Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns. CD14+ cells are monocytes that can differentiate into a host of different cells. CD14 has been shown to interact with Lipopolysaccharide-binding protein.
SKU | AMS.CD4-H5252-1mg |
---|---|
Size | 1 mg |
Species | Human |
Expression Host | HEK293 |
Gene symbol | CD14 |
aa sequence | Thr 20 - Cys 352 |
Tag | FC |
Label/Conjugate | Unconjugated |
Accession No | NP_000582.1 |
Gene description | Human |
Gene synonyms | CD14 |
Format | Powder |
Storage | -20C |
Shipping Temp | RT |
Supplier Name | ACROBiosystems Inc. |