Human CD14 Protein, Fc Tag (MALS verified)

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AMS.CD4-H5252-1mg
$1,790.00
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Cluster of differentiation 14 (CD14), is a cell surface glycoprotein, and is a is a component of the innate immune system. CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa). CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP). CD14 has been proposed to be involved in various biological processes, including transportation of other lipids, cell-cell interaction during different immune responses, as well as recognition of apoptotic cells. Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns. CD14+ cells are monocytes that can differentiate into a host of different cells. CD14 has been shown to interact with Lipopolysaccharide-binding protein.
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SKU AMS.CD4-H5252-1mg
Size 1 mg
Species Human
Expression Host HEK293
Gene symbol CD14
aa sequence Thr 20 - Cys 352
Tag FC
Label/Conjugate Unconjugated
Accession No NP_000582.1
Gene description Human
Gene synonyms CD14
Format Powder
Storage -20C
Shipping Temp RT
Supplier Name ACROBiosystems Inc.