Human BACE-1 Protein|Fc Tag

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AMS.BA1-H5261-1mg
$1,225.00
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Beta-secretase 1 (BACE1) is also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2), C-Secretase , and is a member of the peptidase A1 protein family, BACE1 is a type I  integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. BACE1 is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP). Generation of the 40 or 42 amino acid-long amyloid-C peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the APP. Extracellular cleavage of APP by BACE creates a soluble extracellular fragment and a cell membrane-bound fragment referred to as C99. The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positive-feedback loop in AD.
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SKU AMS.BA1-H5261-1mg
Size 1 mg
Species Human
Expression Host HEK293
Gene symbol BACE-1
aa sequence Thr 22 - Thr 457
Tag FC
Label/Conjugate Unconjugated
Accession No NP_036236.1
Gene id Human BACE-1, Fc Tag (BA1-H5261) is expressed from human 293 cells (HEK293). It contains AA Thr 22 - Thr 457 (Accession # NP_036236.1).
Gene description Human
Gene synonyms BACE1,ASP2,BACE,FLJ90568,HSPC104,KIAA1149,Memapsin-2
Format Powder
Storage -20?
Shipping Temp RT
Supplier Name ACROBiosystems Inc.