PROTACÂ® Optimization Kit for BET Bromodomain-Cereblon Binding

Name: PROTACÂ® Optimization Kit for BET Bromodomain-Cereblon Binding
Brand: 79770
SKU: 79770
Availability: InStock

Product Code

79770

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Overview

The PROTAC Optimization Kit for BET Bromodomain-Cereblon Binding is designed for testing and profiling of PROTACs directed against BET Bromodomain family and Cereblon complex. Cereblon (CRBN) is a Substrate recognition component of a DCX (DDB1-CUL44-Rbx1) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The PROTAC Optimization Kit for BET Bromodomain-Cereblon Binding comes in a convenient AlphaLISAÂ® format|with dBET1 PROTAC|Immuno Buffer 1|and purified BRD3(BD2) and CRBN for 384 reactions. (+)JQ1 is included as a control inhibitor of PROTAC binding to BRD3(BD2). With this kit|only three simple steps on a microtiter plate are required for PROTAC activity detection. First|a sample containing PROTAC is incubated with CRBN and BRD3(BD2)|one of BET bromodomains. Next|acceptor beads are added|then donor beads|followed by reading the Alpha-counts.

Product Specifications

More Information
SKU	79770
Size	384 reactions
Alternate SKU	AMS.79770
Gene synonyms	CRBN, Protein X 0001, MRT2A MRT2
Storage	At least six months from date of receipt when stored as directed.
Shipping Temp	-80C (dry ice)
Supplier Name	BPS

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PROTACÂ® Optimization Kit for BET Bromodomain-Cereblon Binding

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