MAPTrix™ extracellular matrix (ECM) based coatings or surface modification is simple, convenient and highly reproducible. You can readily engineer a synthetic ECM surface that binds to adhesion receptors such as integrins and promote cell adhesion and spreading.

AMSBIO supplies Mussel Adhesive Protein based matrix (MAPTrix^TM) recombinant extracellular matrix (ECM) that act as biometic mimics for traditional basement membrane extracts. MAPTrix^TM replaces traditional ECM with genetically incorporated bioactive peptides (recognition peptides) that provide an environment for the maintenance of cells under serum and feeder-free conditions.

• Biochemically-defined, animal-free cell culture surfaces designed to enhance cell performance.
• Adhesion properties of the mussel adhesive protein makes the coating reproducible & reliable.
• MAPTrix™ produces a uniform ECM surface that provides a highly controlled 2D extracellular microenvironment for cell cultures and related applications.
• A wide array of MAPTrix™ ECM products are currently available (115 ECM lines).
• Low cost compared to traditional ECM.
• Eliminates risk of animal or viral infectious agents in cell cultures.
• Helps comply with FDA recommendations for animal-free component.
• Ready to use and compatible with standard coating protocols.
• Improved cell morphology and cell proliferation.

The MAPTrix^TM ECM line of products are provided with a guaranteed purity of >90% (SDS-PAGE) with endotoxin levels below 20 EU/mL (LAL assay). Each product is tested for the presence of bacteria, fungi and mycoplasma with biological activity of each product determined in a cell culture assay under serum-free conditions.

To view available mimics click here alternatively if you know the type of mimic you are looking for click on the appropriate link below.

Collagen MAPTrix^TM-C
Laminin MAPTrix^TM-L
Fibronectin MAPTrix^TM-F
Vitronectin MAPTrix^TM-V

A promising tool for the in vitro exploration of extracellular microenvironment (ECM) factors that regulate cell functions is the combinatorial library approach. With the use of combinatorial libraries, one can explore the effect of numerous know and unknown factors, alone or in complex combinations in analogous to those encountered in natural extracellular microenvironments. Our MAPTrix™ ECM Library is the first commercially available combinatorial synthetic ECM library. It is comprised of hundreds of ECM derived peptide motifs which primarily bind to specific integrins. When combined with high throughput technology, our MAPTrix™ Array based cell culture systems allows one to investigate and/or optimize ECM cues and cellular signaling events which control cellular functions. The information obtained from the cell culture systems can be translated and applied to creating or engineering biomimetic or synthetic microenvironments in order to regulate cell behavior for biomedical applications.

MAPTrix™ Array offers an extensive line of ECM-derived ligands for high throughput cell adhesion assays to identify a cellular adhesion profile against up to 300 cell surface receptor binding peptide motifs.

Below is an example of the data obtained from an ECM array.