amsbio announces an expanded range of
assay kits enzymes and antibodies for the detection & quantification of
oxidative stress biomarkers and antioxidants.
Reduction of oxygen results in the formation of
reactive oxygen species (ROS), such as
hydrogen peroxide,
hydroxyl radicals and
superoxide. These are directly responsible for the detrimental effects of oxidative stress.
Generation of reactive oxygen species is linked to a variety of environmental factors like ultraviolet radiation & cigarette smoking. To counteract the effects of ROS
in vivo, there are a number of distinct antioxidant mechanisms in place within the cell,
such as superoxide dismutase, catalase, ascorbic acid, and glutathione.
Oxidative stress & associated damage to cellular lipids, proteins and DNA occur when these compensatory mechanisms fail to deal with the increasing loads of ROS.
Elevated levels of ROS contribute to a decline in cellular function, and have been reported to coincide with pathologies including cancer, cardiovascular disease and neurological disorders.