amsbio now supplies
Endothelial Progenitor Cells (EPC) - the primitive cell type in the endothelial lineage that are
bone marrow derived cells with properties similar to those of
embryonic angioblasts.
View the complete range of fresh and cryopreserved human EPC cells and EPC growth medium
here.
Progenitor cells migrate into the blood stream and are able to differentiate into a variety of mature vascular
endothelial cell types. EPCs play an important role in both
angiogenesis,
vasculogenesis and compared to specific mature
types of endothelial cells such as HMVECs and HUVECs. EPC are more suitable for cell-based screening of anti-cancer drugs.
Endothelial progenitor cells also have an impact on aging and smoking-related diseases, suggesting potential use in these areas.
Applications:
- Cancers such as lymphoma, breast cancer, lung cancer and inoperable heptocellular carcinoma
- Vascular diseases such as coronary artery disease (CAD) and acute myocardial infarction.
- Diabetes Mellitus
- Ischemia
- Pulmonary hypertension
- Cerebral vascular disease
- Arthritis
- Cutaneous wound healing and skin regeneration
Features:
- Human primary cells
- Progenitor cells, not terminally differentiated mature endothelial cells such as HUVEC, HMVEC
- Differentiates into specific subtypes of endothelial cells, such as: vein, microvascular and aortic
- Gene expression pattern is more similar to that of endothelial cells from tumors
- Specifically migrate to human tumors
- Quantity and functions in the human blood is altered during pathogenesis of a variety of human diseases